The objective of the study was to outline key considerations for general clinical readers when critically evaluating publications on platform trials and for researchers when designing these types of clinical trials.
In this review, using a series of examples derived from equivalence and non-inferiority/superiority RCTs, we describe the main differences and methodological aspects among these three different types of RCTs
This paper is a practical guide to the essentials of statistical analysis and reporting of randomized clinical trials, include statistical controversies in reporting and interpretation, the fundamentals of trial design, and statistical challenges in the design and monitoring.
Some innovations spread fast. How do you speed the ones that don’t?
Questions about the implementation of evidence-based intervention to treat and prevent HIV have risen to the top of the field’s scientific priorities. This commentary offers several considerations for researchers formulating implementation research questions based on several distinctive features of the field.
It has been suggested that implementation strategies should be selected and tailored to address the contextual needs of a given change effort; however, there is limited guidance as to how to do this. This article proposes four methods that could be used to match implementation strategies to identified barriers and facilitators.
Dissemination of evidence-based recommendations and knowledge brokering have emerged as potential strategies to achieve evidence implementation by influencing resource allocation decisions.
To move the implementation science field forward and to provide a practical tool to apply the knowledge in this field, this article describes a systematic process for planning or selecting implementation strategies: Implementation Mapping.