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NEJM
Adaptive trial design has been proposed as a means to increase the efficiency of randomized clinical trials, potentially benefiting trial participants and future patients while reducing costs and enhancing the likelihood of finding a true benefit, if one exists, of the therapy being studied.
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J Clin Epidemiol
The objective of the study was to outline key considerations for general clinical readers when critically evaluating publications on platform trials and for researchers when designing these types of clinical trials.
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Intern Emerg Med
In this review, using a series of examples derived from equivalence and non-inferiority/superiority RCTs, we describe the main differences and methodological aspects among these three different types of RCTs
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J Am Coll Cardiol
This paper is a practical guide to the essentials of statistical analysis and reporting of randomized clinical trials, include statistical controversies in reporting and interpretation, the fundamentals of trial design, and statistical challenges in the design and monitoring.
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The New Yorker
Some innovations spread fast. How do you speed the ones that don’t?
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JIAS
Questions about the implementation of evidence-based intervention to treat and prevent HIV have risen to the top of the field’s scientific priorities. This commentary offers several considerations for researchers formulating implementation research questions based on several distinctive features of the field.
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J Behav Health Serv Res
It has been suggested that implementation strategies should be selected and tailored to address the contextual needs of a given change effort; however, there is limited guidance as to how to do this. This article proposes four methods that could be used to match implementation strategies to identified barriers and facilitators.
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PLOS Medicine
Dissemination of evidence-based recommendations and knowledge brokering have emerged as potential strategies to achieve evidence implementation by influencing resource allocation decisions.